Autoimmune disease

Autoimmune diseases
Classification and external resources
ICD-10 D84.9, M35.9
ICD-9 279.4
OMIM 109100
DiseasesDB 28805
MedlinePlus 000816
MeSH D001327

Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. In other words, the immune system mistakes some part of the body as a pathogen and attacks its own cells. This may be restricted to certain organs (e.g. in autoimmune thyroiditis) or involve a particular tissue in different places (e.g. Goodpasture's disease which may affect the basement membrane in both the lung and the kidney). The treatment of autoimmune diseases is typically with immunosuppression—medication which decreases the immune response.

Contents

Criteria

For a disease to be regarded as an autoimmune disease, it needs to answer to Witebsky's postulates (first formulated by Ernst Witebsky and colleagues in 1957 and modified in 1994):[1][2]

Classification

It is possible to classify autoimmune diseases by corresponding type of hypersensitivity: type II, type III, or type IV. (No type of autoimmune disease mimics type I hypersensitivity.)[3]

There is an on-going discussion about when a disease should be considered autoimmune, leading to different criteria such as Witebsky's postulates.

Name: Accepted/
suspected		 Hypersensitivity

I, II, III, IV

 Autoantibody Notes
Acute disseminated encephalomyelitis (ADEM) Accepted[4]
Addison's Disease interferon omega; transglutaminase; aromatic acid carboxylase; GAD; HAI; 17 hydroxylase; 21 hydroxylase
Agammaglobulinemia IGHM; IGLL1: CD79A; CD79B; BLNK; LRRC8A
Alopecia areata Accepted[5][6] T-cells
Amyotrophic Lateral Sclerosis
Ankylosing Spondylitis Accepted[7][8][9] ANCA? CD8; HLA-B27
Antiphospholipid syndrome Accepted[4] anti-cardiolipin;anti pyruvate dehydrogenase; β2 glycoprotein I; phosphatidylserine; anti apoH; Annexin A5 HLA-DR7, HLA-B8, HLA-DR2, HLA-DR3
Antisynthetase syndrome
Atopic allergy I
Atopic dermatitis I
Autoimmune aplastic anemia
Autoimmune cardiomyopathy Accepted
Autoimmune enteropathy
Autoimmune hemolytic anemia Accepted II complement activation
Autoimmune hepatitis Accepted cell-mediated anti-mitochondrial antibodies; ANA; anti-smooth muscle antibodies, LKM-1; soluble liver antigen
Autoimmune inner ear disease Accepted [10]
Autoimmune lymphoproliferative syndrome Accepted TNFRSF6; defective Fas-CD95 apoptosis
Autoimmune peripheral neuropathy Accepted
Autoimmune pancreatitis Accepted ANA; anti-lactoferrin antibodiesanti-carbonic anhydrase antibodies; rheumatoid factor
Autoimmune polyendocrine syndrome Accepted Unknown or multiple APS-1 see Addison's Disease
Autoimmune progesterone dermatitis Accepted
Autoimmune thrombocytopenic purpura Accepted anti gpIIb-IIIa or 1b-IX
Autoimmune urticaria Accepted [11]
Autoimmune uveitis Accepted HLAB-27?
Balo disease/Balo concentric sclerosis
Behçet's disease immune-mediated systemic vasculitis; linkage to HLA-B51 (HLA-B27); very different manifestations with ulcers as common symptom; also called Morbus Adamandiades-Behçet
Berger's disease IgA (elevated in 50% of patients), IgA (in mesangial deposits on kidney biopsy)
Bickerstaff's encephalitis Anti-GQ1b 2/3 patients similar to Guillain-Barré syndrome
Blau syndrome overlaps both sarcoidosis and granuloma annulare
Bullous pemphigoid IgG autoantibodies targeting the type XVII collagen component of hemidesmosomes [12]
Cancer
Castleman's disease Over expression of IL-6
Celiac disease Accepted[13][14][15] IV?? Anti-tissue transglutaminase antibodies HLA-DQ8 and DQ2.5
Chagas disease Suspected[16]
Chronic inflammatory demyelinating polyneuropathy Anti-ganglioside antibodies:anti-GM1, anti-GD1a, anti-GQ1b similar to Guillain-Barré syndrome
Chronic recurrent multifocal osteomyelitis LPIN2, D18S60,similar to Majeed syndrome
Chronic obstructive pulmonary disease Suspected[17][18]
Churg-Strauss syndrome p-ANCA
Cicatricial pemphigoid anti-BP-1, anti BP-2 precipitates C3
Cogan syndrome
Cold agglutinin disease Accepted II IgM idiopathic or secondary to leukemia or infection
Complement component 2 deficiency
Contact dermatitis III
Cranial arteritis aka Temporal arteritis; involves giant cells
CREST syndrome Anti-centromere antibodies Anti-nuclear antibodies
Crohns Disease (one of two types of idiopathic inflammatory bowel disease "IBD") Accepted[4] IV Innate immunity; Th17; Th1; ATG16L1; CARD15;XBP1;
Cushing's Syndrome cortisol binding globulin?
Cutaneous leukocytoclastic angiitis neutrophils
Dego's disease Vasculopathy
Dercum's disease Suspected Lipoid tissue.[19]
Dermatitis herpetiformis IgA; anti-epidermal transglutaminase antibodies
Dermatomyositis Accepted[20] histidine-tRNA anti-signal_recognition_peptide Anti-Mi-2 Anti-Jo1.[21] B- and T-cell perivascular inflammatory infiltrate on muscle biopsy
Diabetes mellitus type 1 Accepted[4] IV Glutamic acid decarboxylase antibodies (GADA), islet cell antibodies (ICA), and insulinoma-associated autoantibodies (IA-2), anti-insulin antibodies
Diffuse cutaneous systemic sclerosis anti-nuclear antibodies, anti-centromere and anti-scl70/anti-topoisomerase antibodies[22] COL1A2 and TGF-β1
Dressler's syndrome myocardial neo-antigens formed as a result of the MI
Drug-induced lupus anti-histone
Discoid lupus erythematosus III IL-2 and IFN-gamma>[23]
Eczema LEKTI, SPINK5,[24] filaggrin.,[25] Brain-derived neurotrophic factor (BDNF) and Substance P.[26]
Endometriosis Suspected[27]
Enthesitis-related arthritis[28] . MMP3[29] TRLR2, TLR4,[30] ERAP1[31]
Eosinophilic fasciitis Accepted
Eosinophilic gastroenteritis IgE IL-3, IL-5, GM-CSF, eotaxin
Epidermolysis bullosa acquisita COL7A1
Erythema nodosum
Erthroblastosis fetalis II ABO, Rh, Kell antibodies mother's immune system attacks fetus
Essential mixed cryoglobulinemia
Evan's syndrome
Fibrodysplasia ossificans progressiva ACVR1 Lymphocytes express increased BMP4
Fibrosing aveolitis aka Idiopathic_pulmonary_fibrosis SFTPA1, SFTPA2, TERT, and TERC.[32]
Gastritis serum antiparietal and anti-IF antibodies
Gastrointestinal pemphigoid Accepted
Giant cell arteritis macrophage giant cells
Glomerulonephritis Sometimes IgA see Buerger's Disease for IgA; Membranous glomerulonephritis for IgG; Membranoproliferative/mesangiocapillary GN (Complement activation); Goodpasture's syndrome; Wegener's granulomatosis
Goodpasture's syndrome Accepted[4] II Anti-Basement Membrane Collagen Type IV Protein
Graves' disease Accepted[4] II thyroid autoantibodies (TSHR-Ab) that activate the TSH-receptor (TSHR)
Guillain-Barré syndrome (GBS) Accepted[4] IV Anti-ganglioside
Hashimoto's encephalopathy Accepted[4] IV alpha-enolase[33]
Hashimoto's thyroiditis Accepted[4] IV antibodies against thyroid peroxidase and/or thyroglobulin HLADR5, CTLA-4
Henoch-Schonlein purpura immunoglobulin A (IgA) and complement component 3 (C3)
Herpes gestationis aka Gestational Pemphigoid IgG and C3 misdirected antibodies intended to protect the placenta
Hidradenitis suppurativa Suspected[34]
Hypogammaglobulinemia IGHM, IGLL1, CD79A, BLNK, LRRC8A, CD79B
Idiopathic Inflammatory Demyelinating Diseases a variant of multiple sclerosis
Idiopathic pulmonary fibrosis SFTPA1, SFTPA2, TERT, and TERC.[32]
Idiopathic thrombocytopenic purpura (See Autoimmune thrombocytopenic purpura) Accepted[4] II glycoproteins IIb-IIIa or Ib-IX, immunoglobulin G
IgA nephropathy III? IgA produced from marrow rather than MALT
Inclusion body myositis similar to polymyositis but does not respond to steroid therapy-activated T8 cells
Chronic Inflammatory demyelinating polyneuropathy anti-ganglioside antibodies similar to Guillain–Barré syndrome
Interstitial cystitis Suspected[35] Mast cells
Juvenile idiopathic arthritis aka Juvenile rheumatoid arthritis inconsistent ANA Rheumatoid_factor
Kawasaki's Disease Suspected ITPKC HLA-B51
Lambert-Eaton myasthenic syndrome voltage-gated calcium channels; Q-type_calcium_channel, synaptogagmin, muscarinic acetylcholine receptor M1 HLA-DR3-B8
Leukocytoclastic vasculitis
Lichen planus
Lichen sclerosus
Linear IgA disease (LAD)
Lou Gehrig's disease (Also Amyotrophic lateral sclerosis) VCP, ATXN2, OPTN, FIG4, TARDBP, ANG, VAPB, FUS, SETX, ALS2, SOD1
Lupoid hepatitis aka Autoimmune_hepatitis ANA and SMA,[36] LKM-1 , LKM-2 or LKM-3; antibodies against soluble liver antigen[37][38](anti-SLA, anti-LP) no autoantibodies detected (~20%)
Lupus erythematosus Accepted[4] III Anti-nuclear antibodies[39] anti-Ro.[40] Also, they are often present in Sjögren's syndrome.[41][42]
Majeed syndrome LPIN2
Ménière's disease III? major peripheral myelin protein P0[43]
Microscopic polyangiitis p-ANCA myeloperoxidase binds to neutrophils causing them to degranulate and damages endothelium
Miller-Fisher syndrome see Guillain-Barre_Syndrome Accepted anti-GQ1b
Mixed Connective Tissue Disease Accepted[4] anti-nuclear antibody anti-U1-RNP HLA-DR4
Morphea Suspected[44]
Mucha-Habermann disease aka Pityriasis_lichenoides_et_varioliformis_acuta T-cells
Multiple sclerosis Suspected IV PECAM-1[45] Anti-Myelin Basic Protein
Myasthenia gravis Accepted[4] II nicotinic_acetylcholine_receptor MuSK_protein HA-B8 HLA-DR3 HLA-DR1
Myositis see Dermatomyositis and Polymyositis see Inclusion-body-myositis
Narcolepsy[46][47] Suspected[48] II? hypocretin or orexin[49] HLA-DQB1*0602[50]
Neuromyelitis optica (Also Devic's Disease) II? NMO-IgG aquaporin 4.[51][52]
Neuromyotonia Suspected[53] II? voltage-gated potassium channels.[53]
Occular cicatricial pemphigoid II? BP-1, BP-2 C3 deposition
Opsoclonus myoclonus syndrome Suspected IV? Lymphocyte recruitment to CSF[54]
Ord's thyroiditis
Palindromic rheumatism anti-cyclic citrullinated peptide antibodies (anti-CCP) and antikeratin antibodies (AKA)[55]
PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcus) Suspected II? antibodies against streptococcal infection serve as auto-antibodies
Paraneoplastic cerebellar degeneration IV?[56] II? anti-Yo[57] (anti-cdr-2[58] in purkinje fibers) anti-Hu, anti-Tr, antiglutamate receptor
Paroxysmal nocturnal hemoglobinuria (PNH) Sometimes(?) complement attacks RBCs
Parry Romberg syndrome ANA
Parsonnage-Turner syndrome
Pars planitis
Pemphigus vulgaris Accepted[4] II Anti-Desmoglein 3
Pernicious anaemia Accepted[59] II anti-parietal cell antibody
Perivenous encephalomyelitis
POEMS syndrome interleukin 1β, interleukin 6 and TNFα. vascular endothelial growth factor (VEGF), given the .[60]
Polyarteritis nodosa
Polymyalgia rheumatica
Polymyositis Accepted[61] IFN-gamma, IL-1, TNF-alpha
Primary biliary cirrhosis Accepted[62] Anti-p62, Anti-sp100, Anti-Mitochondrial(M2)Anti-Ro aka SSA.[63] Also, they are often present in Sjögren's syndrome.[64][65]
Primary sclerosing cholangitis overlap with primary biliary cirrhosis?
Progressive inflammatory neuropathy Suspected
Psoriasis Accepted[66] IV? CD-8 T-cells, HLA-Cw6, IL-12b, IL-23b, TNFalpha, nfKb
Psoriatic arthritis Accepted[67] IV? HLA=B27
Pyoderma gangrenosum Can occur in conjunction with other immune-related disorders
Pure red cell aplasia
Rasmussen's encephalitis anti-NR2A antibodies
Raynaud phenomenon Suspected Can occur in conjunction with other immune-related disorders
Relapsing polychondritis Accepted[68]
Reiter's syndrome
Restless leg syndrome Suspected May occur in Sjögren's syndrome, celiac disease, and rheumatoid arthritis or in derangements of iron metabolism
Retroperitoneal fibrosis
Rheumatoid arthritis Accepted[4] III Rheumatoid factor (anti-IgGFc), Anti-MCV , ACPAs(Vimentin HLA-DR4, PTPN22, depleted B cells, TNF alpha, IL-17, (also maybe IL-1, 6, and 15)
Rheumatic_fever II streptococcal M protein cross reacts with human myosin,[69] anti-DNase B, ASO
Sarcoidosis Suspected IV[70][71] BTNL2; HLA-B7-DR15; HLA DR3-DQ2.[72]
Schizophrenia Suspected[73][74][75]
Schmidt syndrome another form of APS anti-21 hydroxylase, anti-17 hydroxylase[76] DQ2, DQ8 and DRB1*0404
Schnitzler syndrome IgM?
Scleritis
Scleroderma Suspected[44] IV? Scl-70 Anti-topoisomerase dysregulated apoptosis?
Serum Sickness III
Sjögren's syndrome Accepted[4] Anti-ro.[77] Also, they are often present in Sjögren's syndrome.[78][79]
Spondyloarthropathy HLA-B27
Still's disease see Juvenile Rheumatoid Arthritis ANA macrophage migration inhibitory factor[80]
Stiff person syndrome Suspected glutamic acid decarboxylase (GAD),[81] GLRA1 (glycine receptor
Subacute bacterial endocarditis (SBE) III [82] essential mixed cryoglobulinemia
Susac's syndrome
Sweet's syndrome GCSF
Sydenham chorea see PANDAS
Sympathetic ophthalmia ocular antigens following trauma
Systemic lupus erythematosis see Lupus erythematosis III
Takayasu's arteritis
Temporal arteritis (also known as "giant cell arteritis") Accepted[4] IV
Thrombocytopenia II glycoproteins IIb-IIIa or Ib-IX in ITP anti-ADAMTS13 in TTP.[83] and HUS anti-cardiolipin (anti-cardiolipin antibodies) and β2 glycoprotein I in Antiphospholipid syndrome anti-HPA-1a, anti-HPA-5b, and others[84] in NAIT muliple mechanisms
Tolosa-Hunt syndrome
Transverse myelitis Accepted Transverse Myelitis is a rare neurological disorder that is part of a spectrum of neuroimmunologic diseases of the central nervous system. http://www.myelitis.org/
Ulcerative colitis (one of two types of idiopathic inflammatory bowel disease "IBD") Accepted[4] IV
Undifferentiated connective tissue disease different from Mixed connective tissue disease Accepted anti-nuclear antibody HLA-DR4
Undifferentiated spondyloarthropathy
Urticarial vasculitis II? anti C1q antibodies[85] clinically may resemble type I hypersensitivity!
Vasculitis Accepted[86] III sometimes ANCA
Vitiligo Suspected[87][88] NALP-1 RERE, PTPN22, LPP, IL2RA, GZMB, UBASH3A and C1QTNF6
Wegener's granulomatosis Accepted[89] Anti-neutrophil cytoplasmic(cANCA)

Development of therapies

In both autoimmune and inflammatory diseases the condition arises through aberrant reactions of the human adaptive or innate immune systems. In autoimmunity, the patient’s immune system is activated against the body's own proteins. In inflammatory diseases, it is the overreaction of the immune system, and its subsequent downstream signaling (TNF, IFN, etc.), which causes problems.

A substantial minority of the population suffers from these diseases, which are often chronic, debilitating, and life-threatening. There are more than eighty illnesses caused by autoimmunity.[90] It has been estimated that autoimmune diseases are among the ten leading causes of death among women in all age groups up to 65 years.[91]

See also

References

  1. ^ Witebsky E, Rose NR, Terplan K, Paine JR, Egan RW (1957). "Chronic thyroiditis and autoimmunization". J. Am. Med. Assoc. 164 (13): 1439–47. doi:10.1001/jama.1957.02980130015004. PMID 13448890. 
  2. ^ Rose NR, Bona C (September 1993). "Defining criteria for autoimmune diseases (Witebsky's postulates revisited)". Immunol. Today 14 (9): 426–30. doi:10.1016/0167-5699(93)90244-F. PMID 8216719. 
  3. ^ Parham, Peter (2005). The immune system. New York: Garland Science. pp. 344. ISBN 0-8153-4093-1. 
  4. ^ a b c d e f g h i j k l m n o p q r MeSH Autoimmune+Diseases
  5. ^ American Academy of Dermatology, http://www.aad.org/public/publications/pamphlets/common_alopecia.html
  6. ^ htmlThe University of Texas MD Anderson Cancer Center, http://www.mdanderson.org/patient-and-cancer-information/cancer-information/cancer-types/alopecia-areata/index.html
  7. ^ HLA-B27 and Ankylosing Spondylitis, http://www.hlab27.com
  8. ^ Inflammatory Diseases of Immune Dysregulation, http://www.idid.us
  9. ^ Khan MA, Khan MK (1982). "Diagnostic Value of HLA-B27 Testing in Ankylosing Spondylitis and Reiter's Syndrome". Annals of Internal Medicine January 1, 1982 vol. 96 no. 1 70-76 96 (1): 70–76; author reply 76. PMID 7053711. 
  10. ^ "Autoimmune Inner Ear Disease, Baylor College of Medicine". 1993. http://www.bcm.edu/oto/grand/4893.html. 
  11. ^ Soundararajan S, Kikuchi Y, Kusumam J, Kaplan AP (2004). "Functional | assessment of pathogenic IgG subclass in chronic autoimmune urticaria". Journal of Allergy and Clinical 115 (4): 815–21. doi:10.1016/j.jaci.2004.12.1120. 
  12. ^ "Autoimmune Disorders: Immune Disorders: Merck Manual Home Health Handbook". http://www.merckmanuals.com/home/immune_disorders/autoimmune_disorders/autoimmune_disorders.html. 
  13. ^ "Celiac Disease". http://digestive.niddk.nih.gov/ddiseases/pubs/celiac/#1. 
  14. ^ Meize-Grochowski R (2005). "Celiac disease: a multisystem autoimmune disorder". Gastroenterol Nurs 28 (5): 394–402; quiz 403–4. doi:10.1097/00001610-200509000-00005. PMID 16234635. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=1042-895X&volume=28&issue=5&spage=394. 
  15. ^ Sollid LM, Jabri B (December 2005). "Is celiac disease an autoimmune disorder?". Curr. Opin. Immunol. 17 (6): 595–600. doi:10.1016/j.coi.2005.09.015. PMID 16214317. http://linkinghub.elsevier.com/retrieve/pii/S0952-7915(05)00158-5. 
  16. ^ Hyland KV, Engman DM (2006). "Further thoughts on where we stand on the autoimmunity hypothesis of Chagas disease". Trends Parasitol. 22 (3): 101–2; author reply 103. doi:10.1016/j.pt.2006.01.001. PMID 16446117. 
  17. ^ Agustí A, MacNee W, Donaldson K, Cosio M. (2003). "Hypothesis: does COPD have an autoimmune component?". Thorax 58 (10): 832–834. doi:10.1136/thorax.58.10.832. PMC 1746486. PMID 14514931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1746486. 
  18. ^ Lee SH, Goswami S, Grudo A, et al (2007). "Antielastin autoimmunity in tobacco smoking-induced emphysema". Nat. Med. 13 (5): 567–9. doi:10.1038/nm1583. PMID 17450149. 
  19. ^ Singal A, Janiga JJ, Bossenbroek NM, Lim HW (May 2007). "Dercum's disease (adiposis dolorosa): a report of improvement with infliximab and methotrexate". J Eur Acad Dermatol Venereol 21 (5): 717. doi:10.1111/j.1468-3083.2006.02021.x. PMID 17448013. http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0926-9959&date=2007&volume=21&issue=5&spage=717. 
  20. ^ "Polymyositis and Dermatomyositis: Autoimmune Disorders of Connective Tissue: Merck Manual Home Health Handbook". http://www.merckmanuals.com/home/bone_joint_and_muscle_disorders/autoimmune_disorders_of_connective_tissue/polymyositis_and_dermatomyositis.html. 
  21. ^ Ghirardello, A; Zampieri S, Tarricone E et al. (May 2006). "Clinical implications of autoantibody screening in patients with autoimmune myositis". Autoimmunity 39 (3): 217–221. doi:10.1080/08916930600622645. PMID 16769655. 
  22. ^ Jimenez SA, Derk CT (2004). "Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis". Ann. Intern. Med. 140 (1): 37–50. PMID 14706971. 
  23. ^ Toro JR, Finlay D, Dou X, Zheng SC, LeBoit PE, Connoly KM. "Detection of Type 1 Cytokines in Discoid Lupus Erythematosus". Annals of Internal Medicine 2000 136: 1497–1501. 
  24. ^ Walley AJ, Chavanas S, Moffatt MF, et al. (2001). "Gene polymorphism in Netherton and common atopic disease". Nat. Genet. 29 (2): 175–8. doi:10.1038/ng728. PMID 11544479. 
  25. ^ Palmer CN et al. (2006). "Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis". Nature Genetics 38 (4): 441–6. doi:10.1038/ng1767. PMID 16550169. 
  26. ^ "'Blood chemicals link' to eczema -- Scientists have identified two blood chemicals linked to itchy eczema, offering new treatment possibilities.". BBC News. 26 August 2007. http://news.bbc.co.uk/2/hi/health/6962450.stm. Retrieved 2007-10-16. 
  27. ^ Gleicher N, el-Roeiy A, Confino E, Friberg J (1987). "Is endometriosis an autoimmune disease?". Obstetrics and gynecology 70 (1): 115–22. PMID 3110710. 
  28. ^ Colbert RA. "Classification of juvenile spondyloarthritis: Enthesitis-related arthritis and beyond". Nat Rev Rheumatol. 2010 Aug 6 (8): 477–85. 
  29. ^ Viswanath V, Myles A, Dayal R, Aggarwal A. "Levels of Serum Matrix Metalloproteinase-3 Correlate with Disease Activity in the Enthesitis-related Arthritis Category of Juvenile Idiopathic Arthritis". J Rheumatol 2011 Sep1. 
  30. ^ Myles A, Aggarwal A (March 2011). "Expression of Toll-like receptors 2 and 4 is increased in peripheral blood and synovial fluid monocytes of patients with enthesitis-related arthritis subtype of juvenile idiopathic arthritis". Rheumatology (Oxford) 2011 Mar 50 (3): 481–8. doi:10.1093/rheumatology/keq362. PMID 21097451. 
  31. ^ Hinks A, Martin P, Flynn E, Eyre S, Packham J; Childhood Arthritis Prospective Study (CAPS); BSPAR study group, Barton A, Worthington J, Thomson W. (2001). "Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis". Arthritis Res Ther 13 (1): R12. doi:10.1186/ar3235. PMID 21281511. 
  32. ^ a b Online 'Mendelian Inheritance in Man' (OMIM) 178500
  33. ^ Yoneda M, Fujii A, Ito A, Yokoyama H, Nakagawa H, Kuriyama M (April 2007). "High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy". J. Neuroimmunol. 185 (1-2): 195–200. doi:10.1016/j.jneuroim.2007.01.018. PMID 17335908. 
  34. ^ "Clinical Trial: Etanercept in Hidradenitis Suppurativa". http://clinicaltrials.gov/show/NCT00329823. Retrieved 2007-07-08. 
  35. ^ Kárpáti F, Dénes L, Büttner K (1975). "[Interstitial cystitis=autoimmune cyatitis? Interstitial as a participating disease in lupus erythematosus]" (in German). Zeitschrift für Urologie und Nephrologie 68 (9): 633–9. PMID 1227191. 
  36. ^ Bogdanos DP, Invernizzi P, Mackay IR, Vergani D (June 2008). "Autoimmune liver serology: Current diagnostic and clinical challenges". World J. Gastroenterol. 14 (21): 3374–3387. doi:10.3748/wjg.14.3374. PMC 2716592. PMID 18528935. http://www.wjgnet.com/1007-9327/14/3374.asp. 
  37. ^ "autoimmune hepatitis". http://www.meddean.luc.edu/Lumen/MedEd/orfpath/autoimmune%20hepatitis.htm. 
  38. ^ "Medscape & eMedicine Log In". http://www.medscape.com/viewarticle/445619_14. 
  39. ^ Ehrenstein MR (August 1999). "Antinuclear antibodies and lupus: causes and consequences". Rheumatology (Oxford) 38 (8): 691–3. doi:10.1093/rheumatology/38.8.691. PMID 10501412. http://rheumatology.oxfordjournals.org/content/38/8/691.full. 
  40. ^ Franceschini, F.; Cavazzana, I. (2005). "Anti-Ro/SSA and La/SSB antibodies". Autoimmunity 38 (1): 55–63. doi:10.1080/08916930400022954. PMID 15804706.  edit
  41. ^ Franceschini F, Cavazzana I (February 2005). "Anti-Ro/SSA and La/SSB antibodies". Autoimmunity 38 (1): 55–63. doi:10.1080/08916930400022954. PMID 15804706. 
  42. ^ V Goëb et al. (2007). "Clinical significance of autoantibodies recognizing Sjögren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjögren's syndrome". Clin. Exp. Immunol. 148 (2): 281–7. doi:10.1111/j.1365-2249.2007.03337.x. PMC 1868868. PMID 17286756. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1868868. 
  43. ^ Boulassel MR, Deggouj N, Tomasi JP, Gersdorff M. (2001 Jan). Inner ear autoantibodies and their targets in patients with autoimmune inner ear diseases.. 12. pp. 28–34.. 
  44. ^ a b Takehara K, Sato S (2005). "Localized scleroderma is an autoimmune disorder". Rheumatology (Oxford, England) 44 (3): 274–9. doi:10.1093/rheumatology/keh487. PMID 15561734. 
  45. ^ Kalinowska A, Losy J. (2006). "PECAM-1, a key player in neuroinflammation". Eur J Neurol 13 (12): 1284-90274. PMID pmid14754395. 
  46. ^ Hallmayer J, Faraco J, Lin L, et al. (June 2009). "Narcolepsy is strongly associated with the TCR alpha locus". Nat. Genet. 41 (6): 708–11. doi:10.1038/ng.372. PMC 2803042. PMID 19412176. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2803042. 
  47. ^ "Narcolepsy is an autoimmune disorder, Stanford researcher says". EurekAlert. American Association for the Advancement of Science. 2009-05-03. http://www.eurekalert.org/pub_releases/2009-05/sumc-nia042809.php. Retrieved 2009-05-31. 
  48. ^ Carlander, B., Eliaou J.F., Billiard M. (1993). "Autoimmune hypothesis in narcolepsy.". Neurophysiol. Clin. 23: 15. doi:10.1016/S0987-7053(05)80279-5. 
  49. ^ Mignot, E (2001). "A commentary on the neurobiology of the hypocretin/orexin system". Neuropsychopharmacology 25 (5 Suppl): S5–13. doi:10.1016/S0893-133X(01)00316-5. PMID 11682267. 
  50. ^ Maret, S; Tafti M (November 2005). "Genetics of narcolepsy and other major sleep disorders" (PDF). Swiss Medical Weekly (EMH Swiss Medical Publishers Ltd.) 135 (45–46): 662–5. PMID 16453205. http://www.smw.ch/docs/pdf200x/2005/45/smw-11162.pdf. Retrieved 2008-03-07. 
  51. ^ Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR (2005). "IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel". J. Exp. Med. 202 (4): 473–477. doi:10.1084/jem.20050304. PMC 2212860. PMID 16087714. http://www.jem.org/cgi/content/full/202/4/473. 
  52. ^ Pittock SJ, Weinshenker BG, Lucchinetti CF, Wingerchuk DM, Corboy JR, Lennon VA (2006). "Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression". Arch. Neurol. 63 (7): 964–968. doi:10.1001/archneur.63.7.964. PMID 16831965. http://archneur.ama-assn.org/cgi/content/full/63/7/964. 
  53. ^ a b Maddison P (2006). "Neuromyotonia". Clinical Neurophysiology 117 (10): 2118–27. doi:10.1016/j.clinph.2006.03.008. PMID 16843723. 
  54. ^ Pranzatelli, M. R., Travelstead, A. L., Tate, E. D., Allison, T. J.,Moticka, E. J., Franz, D. N., Nigro, M. A., Parke, J. T., Stumpf, D. A., Verhulst, S. J. (2004). "B- and T-cell markers in opsoclonus-myoclonus syndrome: Immunophenotyping of CSF lymphocytes". Neurology 62 (9): 1526-1532. PMID 15136676. 
  55. ^ Powell A, Davis P, Jones N, Russell AS (June 2008). "Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients". J. Rheumatol. 35 (6): 992–4. PMID 18412310. http://www.jrheum.com/subscribers/08/06/992.html. 
  56. ^ Darnell,R.B. (1996), "Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain", Proc Natl Acad Sci U S A 93 (10): 4529-4536, PMC 39311, PMID 8643438, http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39311 
  57. ^ Peterson,K., Rosenblum, J.K., Kotanides,H., Posner,J.B. (1992), "Paraneoplastic cerebellar degeneration. I. A clinical analysis of 55 anti-Yo antibody-positive patients", Neurology 42 (10): 1931-1937, PMID 1407575 
  58. ^ Albert,M.L., Austin,L.M., Darnell,R.B. (2000), "Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration", Ann Neurol 47 (1): 9-17, PMID 10632096 
  59. ^ "MedlinePlus Medical Encyclopedia: Pernicious anemia". http://www.nlm.nih.gov/medlineplus/ency/article/000569.htm. Retrieved 2008-04-05. 
  60. ^ Dispenzieri A, Kyle RA, Lacy MQ, et al. (2003). "POEMS syndrome: definitions and long-term outcome". Blood 101 (7): 2496–506. doi:10.1182/blood-2002-07-2299. PMID 12456500. http://bloodjournal.hematologylibrary.org/cgi/content/full/101/7/2496. 
  61. ^ "Polymyositis and Dermatomyositis: Autoimmune Disorders of Connective Tissue: Merck Manual Home Health Handbook". http://www.merckmanuals.com/home/bone_joint_and_muscle_disorders/autoimmune_disorders_of_connective_tissue/polymyositis_and_dermatomyositis.html. 
  62. ^ Franceschini, F.; Cavazzana, I. (2005). "Anti-Ro/SSA and La/SSB antibodies". Autoimmunity 38 (1): 55–63. doi:10.1080/08916930400022954. PMID 15804706.  edit
  63. ^ Franceschini F, Cavazzana I (February 2005). "Anti-Ro/SSA and La/SSB antibodies". Autoimmunity 38 (1): 55–63. doi:10.1080/08916930400022954. PMID 15804706. 
  64. ^ V Goëb et al. (2007). "Clinical significance of autoantibodies recognizing Sjögren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjögren's syndrome". Clin. Exp. Immunol. 148 (2): 281–7. doi:10.1111/j.1365-2249.2007.03337.x. PMC 1868868. PMID 17286756. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1868868. 
  65. ^ National Psoriasis Foundation, http://www.psoriasis.org/home/learn01.php
  66. ^ National Psoriasis Foundation, http://www.psoriasis.org/home/learn02.php
  67. ^ "Relapsing Polychondritis: Autoimmune Disorders of Connective Tissue: Merck Manual Home Health Handbook". http://www.merckmanuals.com/home/bone_joint_and_muscle_disorders/autoimmune_disorders_of_connective_tissue/relapsing_polychondritis.html. 
  68. ^ Faé KC, da Silva DD, Oshiro SE, et al. (May 2006). "Mimicry in recognition of cardiac myosin peptides by heart-intralesional T cell clones from rheumatic heart disease". J. Immunol. 176 (9): 5662–70. PMID 16622036. http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=16622036. 
  69. ^ "eMedicine - Hypersensitivity Reactions, Delayed : Article by Walter Duane Hinshaw". http://www.emedicine.com/MED/topic1100.htm. Retrieved 2008-09-18. 
  70. ^ Morell F, Levy G, Orriols R, Ferrer J, De Gracia J, Sampol G (April 2002). "Delayed cutaneous hypersensitivity tests and lymphopenia as activity markers in sarcoidosis". Chest 121 (4): 1239–44. doi:10.1378/chest.121.4.1239. PMID 11948059. http://www.chestjournal.org/cgi/pmidlookup?view=long&pmid=11948059. 
  71. ^ Grunewald J, Eklund A, Olerup O (March 2004). "Human leukocyte antigen class I alleles and the disease course in sarcoidosis patients". Am. J. Respir. Crit. Care Med. 169 (6): 696–702. doi:10.1164/rccm.200303-459OC. PMID 14656748. 
  72. ^ Eaton WW, Byrne M, Ewald H, et al (2006). "Association of schizophrenia and autoimmune diseases: linkage of Danish national registers". The American journal of psychiatry 163 (3): 521–8. doi:10.1176/appi.ajp.163.3.521. PMID 16513876. 
  73. ^ Jones AL, Mowry BJ, Pender MP, Greer JM (2005). "Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis?". Immunol. Cell Biol. 83 (1): 9–17. doi:10.1111/j.1440-1711.2005.01305.x. PMID 15661036. 
  74. ^ Strous RD, Shoenfeld Y (2006). "Schizophrenia, autoimmunity and immune system dysregulation: a comprehensive model updated and revisited". J. Autoimmun. 27 (2): 71–80. doi:10.1016/j.jaut.2006.07.006. PMID 16997531. 
  75. ^ de Carmo Silva R, Kater CE, Dib SA, et al (February 2000). "Autoantibodies against recombinant human steroidogenic enzymes 21-hydroxylase, side-chain cleavage and 17alpha-hydroxylase in Addison's disease and autoimmune polyendocrine syndrome type III". Eur. J. Endocrinol. 142 (2): 187–94. doi:10.1530/eje.0.1420187. PMID 10664529. http://eje-online.org/cgi/pmidlookup?view=long&pmid=10664529. Retrieved 2008-07-25. 
  76. ^ Franceschini, F.; Cavazzana, I. (2005). "Anti-Ro/SSA and La/SSB antibodies". Autoimmunity 38 (1): 55–63. doi:10.1080/08916930400022954. PMID 15804706.  edit
  77. ^ Franceschini F, Cavazzana I (February 2005). "Anti-Ro/SSA and La/SSB antibodies". Autoimmunity 38 (1): 55–63. doi:10.1080/08916930400022954. PMID 15804706. 
  78. ^ V Goëb et al. (2007). "Clinical significance of autoantibodies recognizing Sjögren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjögren's syndrome". Clin. Exp. Immunol. 148 (2): 281–7. doi:10.1111/j.1365-2249.2007.03337.x. PMC 1868868. PMID 17286756. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1868868. 
  79. ^ De Benedetti F, Meazza C, Vivarelli M, et al. (May 2003). "Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis". Arthritis Rheum. 48 (5): 1398–407. doi:10.1002/art.10882. PMID 12746913. 
  80. ^ Murinson BB (2004). "Stiff-person syndrome". Neurologist 10 (3): 131–7. doi:10.1097/01.nrl.0000126587.37087.1a. PMID 15140273. 
  81. ^ J. Am. Soc. Nephrol. 8 (12): 1971–6, December 1997, PMID 9402102, http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=9402102 
  82. ^ Moake JL (2004). "von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura". Semin. Hematol. 41 (1): 4–14. doi:10.1053/j.seminhematol.2003.10.003. PMID 14727254. 
  83. ^ Mueller-Eckhardt C, Kiefel V, Grubert A, Kroll H, Weisheit M, Schmidt S et al. (1989). "348 cases of fetal alloimmune thrombocytopenia". Lancet 1: 363–6. 
  84. ^ Wisnieski JJ, Naff GB (September 1989). "Serum IgG antibodies to C1q in hypocomplementemic urticarial vasculitis syndrome". Arthritis Rheum 32 (9): 1119–27. PMID 2528353. 
  85. ^ "Autoimmune Disorders: Immune Disorders: Merck Manual Home Health Handbook". http://www.merckmanuals.com/home/immune_disorders/autoimmune_disorders/autoimmune_disorders.html. 
  86. ^ "Questions and Answers about Vitiligo". http://www.niams.nih.gov/hi/topics/vitiligo/vitiligo.htm. Retrieved 2007-08-06. 
  87. ^ "A New Gene Linked to Vitiligo and Susceptibility to Autoimmune Disorders - Journal Watch Dermatology". http://dermatology.jwatch.org/cgi/content/full/2007/330/1. Retrieved 2007-08-06. 
  88. ^ Sánchez-Cano D, Callejas-Rubio JL, Ortego-Centeno N (April 2008). "Effect of rituximab on refractory Wegener granulomatosis with predominant granulomatous disease". J Clin Rheumatol 14 (2): 92–3. doi:10.1097/RHU.0b013e31816b4487. PMID 18391678. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00124743-200804000-00008. 
  89. ^ National Institutes of Health
  90. ^ Noel R. Rose and Ian R. MacKay, “The Autoimmune Diseases” fourth edition

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